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KMID : 0043319960190010036
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Archives of Pharmacal Research
1996 Volume.19 No. 1 p.36 ~ p.40
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Effect of Glycyrrhetinic acid on Histamine Synthesis and Release
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Lee Young-Mi
Kim Youn-Chul
Kim Hyung-Min
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Abstract
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The effect of glycyrrhetinic acid(18.betha.-glycyrrhetinic acid, GA) on histamine synthesis and release was investigated in cocultured mast cells with Swiss 3T3 fibroblasts. GA has strong dose dependent inhibitory activity for histamine synthesis and release in cocultured mast cells. GA(50 .mu.M) inhibited about 85% of histidine decarboxylase (HDC) activity. The appearance of cells staining positively with berberine sulface was also decreased in the presence of GA. It indicates that transdifferentiation of cultured mas cells (CMCs) was also inhibited.
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KEYWORD
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Histidine, Decarboxylase, Swiss 3T3 fibroblast, Mast cell, Glycyrrhetnic Acid
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